MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF HETEROAROMATIC CARBOXYLIC ACIDS USING MICROORGANISMS OF THE GENUS ALCALIGENES

摘要

A microbiological process for the preparation of heteroaromatic carboxylic acids or physiologically tolerated salts thereof, of the general formulae: <IMG> <IMG> I II in which R1 and R2 are identical or different and denote a hydrogen or halogen atom and X denotes a nitrogen atom or -CH-, is described herein. The conversion is carried out in such a way that heteroaromatic nitriles of the general formulae: <IMG> <IMG> III IV in which R1, R2 and X are as previously defined, are converted as substrate, using 2-cyanopyridine-utilizing microorganisms of the genus Alcaligenes which have been cultured before the biotransformation in the presence of a dicarboxylic acid, tricarboxylic acid or a carbohydrate, into the corresponding carboxylic acid, and the latter is converted where appropriate into a physiologically tolerated salt thereof.