| 发明名称 |
HIGH AFFINITY OLIGONUCLEOTIDE LIGANDS TO GROWTH FACTORS |
| 摘要 |
Methods are described for the identification and preparation of high-affinity nucleic acid ligands to TGF.beta., PDGF and hKGF. Included in the invention are specific RNA and ssDNA ligands to TGF.beta.1 and PDGF identified by the SELEX method. Also included in the invention are specific RNA ligands to hKGF identified by the SELEX method. Further included are RNA ligands that inhibit the interaction of TGF.beta.1 and hKGF with their receptors and DNA ligands that inhibit the interaction of PDGF with its receptor. |
| 申请公布号 |
CA2221318(A1) |
申请公布日期 |
1996.12.05 |
| 申请号 |
CA19962221318 |
申请日期 |
1996.05.30 |
| 申请人 |
NEXSTAR PHARMACEUTICALS, INC. |
发明人 |
PAGRATIS, NIKOS;JANJIC, NEBOJSA;GOLD, LARRY;TOOTHMAN, PENELOPE J.;RINGQUIST, STEVEN |
| 分类号 |
G01N33/50;A61K31/7088;A61P9/00;A61P17/00;A61P17/06;A61P29/00;A61P35/00;A61P43/00;C07K14/475;C07K14/49;C07K14/495;C07K14/50;C12N15/09;C12N15/11;C12N15/115;C12P19/34;C12Q1/68;G01N33/15;(IPC1-7):C12Q1/68;C07H21/00;G01N33/53;G01N33/566;A61K31/70 |
主分类号 |
G01N33/50 |
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