1-BENZOYL-2-(INDOLYL-3-ALKYL)-PIPERAZINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS

摘要

This invention relates to compounds of generic formula (I), to a process for pre paration thereof, to a pharmaceutical composition comprising the same, and to a use of the same as a medicament. In formula (I), R1 is trihalo(lower)alkyl, R2 is trihalo(lower)alkyl, R3 is indolyl(lower)alkyl, -A- is -CH2- or (a), and -R4 is (b), (c) or (d) in which R5 is hydrogen or lower alkoxycarbonyl, R6 is hydrogen or lower alkanoyl, R7 is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, low er alkoxy(lower)alkanoyl, cyclo(lower)alkylcarbonyl, aroyl or lower alkylsulfonyl, or its pharmaceutically acceptable salt.