1-BENZOYL-2-(INDOLYL-3-ALKYL)-PIPERAZINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS

摘要

This invention relates to compounds of generic formula (I), to a process for preparation thereof, to a pharmaceutical composition comprising the same, and to a use of the same as a medicament. In formula (Ig), R<1> is trihalo(lower)alkyl, R<2> is trihalo(lower)alkyl, R<3> is indolyl(lower)alkyl, -A- is -CH2- or (a), and -R<4> is (b), (c) or (d) in which R<5> is hydrogen or lower alkoxycarbonyl, R<6> is hydrogen or lower alkanoyl, R<7> is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, lower alkoxy(lower)alkanoyl, cyclo(lower)alkylcarbonyl, aroyl or lower alkylsulfonyl, or its pharmaceutically acceptable salt.