| 摘要 |
<p>Compounds represented by general formula (I) and having a β-(optionally substituted imidazo[5,1-b]thiazolyl)vinyl group at the 3-position of the cephem ring, and salts and esters thereof. These compounds have an extremely broad antimicrobial spectrum and exerts potent antimicrobial effects on Gram-positive bacteria, Gram-negative bacteria and even resistant bacteria. In formula (I) X represents CH or N; R1 represents hydrogen or an amino protecting group; R2 represents hydrogen, C¿1-6? alkyl, C3-7 cycloalkyl or a hydroxy protecting group; R?3¿ is not present or represents hydrogen, a cation forming a salt or a carboxy protecting group; R?4, R5 and R6¿ may be the same or different and each represents hydrogen or C¿1-6? alkyl; R?7+¿ is not present or represents a cation of C¿1-6? alkyl; and n is an integer of 0 or 1.</p> |
