| 摘要 |
PURPOSE: To obtain the subject therapeutic agent comprising a dihydro- prostaglandin F2βderivative or its salt as an active ingredient, having excellent vasodilating action on constriction of blood vessel of retina, effective for retinal circulatory disorder. CONSTITUTION: This therapeutic agent for retinopathy comprises a 13,14-dihydro- prostaglandin F2βderivative of the formula (R is H, a lower alkyl, a cycloalkyl, phenyl or a phenyl lower alkyl) or its salt as an active ingredient. A compound wherein R is H or isopropyl is preferable among the compounds of the formula. The objective therapeutic agent, for example, can be prepared as an eye drop by using an isotonizing agent such as concentrated glycerol, a buffering agent such as sodium phosphate, etc., an antiseptic such as paraben, etc. The preparation is preferably carried out at pH4 to pH8. A daily dose is preferably 0.1-50mg in the case of an injection and administered once or several times dividedly. In the case of an eye drop, 0.02-0.1% solution is dropped once to several times daily.
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