发明名称 |
METHOD FOR MONITORING THE PROCESSING OF BETA-AMYLOID PRECURSOR PROTEIN (BETAAPP) AND ANTIBODIES BINDING THERETO |
摘要 |
Processing of beta -amyloid precursor protein ( beta APP) is monitored by detecting the secretion of a soluble beta APP fragment resulting from cleavage of beta APP at the amino-terminus of beta -amyloid peptide. In vivo monitoring of secretion of the beta APP fragment may be monitored for diagnosis and prognosis of Alzheimer's disease and other beta -amyloid-related diseases, while in vitro monitoring of such secretion from cultured cells may be monitored to identify inhibitors of beta -amyloid production. The beta APP fragment may be detected using antibodies and other specific binding substances which recognize a carboxy-terminal residue on the fragment.
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申请公布号 |
NZ251053(A) |
申请公布日期 |
1996.11.26 |
申请号 |
NZ19930251053 |
申请日期 |
1993.03.03 |
申请人 |
ATHENA NEUROSCIENCES INC;ELI LILLY & CO |
发明人 |
SEUBERT, PETER A;SCHENK, DALE B;FRITZ, LAWRENCE |
分类号 |
G01N33/53;C07K14/47;C07K16/00;C07K16/18;C12N15/02;C12N15/85;C12P21/08;C12R1/91;G01N33/50;G01N33/68;(IPC1-7):G01N33/53;A61K39/395;C07K14/435 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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