| 摘要 |
PURPOSE: To prepare a composition, comprising bezenapril or its salt and a thiazide diuretic agent and capable of treating a lesser degree to a medium degree of hypertension in a lower dose than that when used alone. CONSTITUTION: This composition comprises bezenapril in about 4-6mg, preferably about 5mg dose at a time or its pharmaceutically permissible salt and a thiazide diuretic agent in an amount of 80-120%, preferably 100% based on 1/8 of the minimal antihyopertensive initial dose recommended when used alone. Bendroflumethiazide, Chlorthalidone, Chlorothiazide, hydrochlorothiazide, hydroflumethiazide, methylchlorothiazide, polythiazide, trichloromethiazide, benzthiazide and dichloroazide are cited as the thiazide diuretic agent. The most preferred composition comprises bezenapril hydrochloride and hydrochlorothiazide at about 0.8-1 weight ratio. |
