Methods for modulating t cell survival by modulating bcl-xl protein level

摘要

Methods for protecting a T cell from cell death are described. The methods involve contacting the T cell with an agent which augments the bcl-XL protein level in the T cell such that it is protected from cell death. The invention further pertains to methods for increasing the susceptibility of a T cell to cell death, comprising contacting the T cell with at least one agent which decreases bcl-XL protein level in the T cell. Both in vivo and in vitro methods are described.