| 摘要 |
<p>PURPOSE: To obtain a hydroindan-4-ol derivative which is useful as a synthetic intermediate for vitamin D derivatives as a medicine in high stereoselectivity. CONSTITUTION: This objective compound is represented by formula I [R<1> and R<2> are each H, OH-protecting group; R<3> is H, a (substituted) alkyl, an alkenyl, an alkynyl, an aryl, an aralky], for example, octahydro-7a-methyl-1-(1-hydroxy-2- propyl)-1H-indene-4-ol. This compound is prepared by allowing a base such as lithium amide to react with an acetic ester derivative of formula II (R<4> is identical to R<3> ) in a solvent such as diethyl ether and allowing the product of enolate to act on 3-(4-hydroxyhydroindan)butanal derivative of formula III (R<5> is identical to R<1> ), when necessary, followed by OH protection or deprotection.</p> |
