Viral attachment inhibitors

摘要

Viral attachment to target cells is inhibited by novel neuraminic acid compounds of the formula: <IMAGE> wherein R1 is selected from the group consisting of hydrogen and acetyl; R2 is selected from the group consisting of hydrogen and methyl; and Y is selected from the group consisting of: <IMAGE> The novel compounds bind virus particles and are substantially uncleaved by neuraminidase. Coupling of the novel compounds to a polymer further inhibits viral attachment.