| 发明名称 |
Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
| 摘要 |
A method for acylating peptides and proteins with the CoA-ester of diheteroatom substituted C13 to C14 myristic acid analogs catalyzed by N-myristoyltransferase is presented. In the analogs, two non-adjacent methylene groups, which are normally at positions 3-13, are replaced with oxygen or sulfur atoms.
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| 申请公布号 |
US5571689(A) |
申请公布日期 |
1996.11.05 |
| 申请号 |
US19940218399 |
申请日期 |
1994.03.28 |
| 申请人 |
WASHINGTON UNIVERSITY |
发明人 |
HEUCKEROTH, ROBERT O.;ADAMS, STEVEN P.;GORDON, JEFFREY I.;GOKEL, GEORGE W. |
| 分类号 |
A61K31/20;A61K31/23;C07C59/125;C07C59/60;C07C323/12;C07C323/52;C07K1/00;C07K1/107;C12N9/10;(IPC1-7):C12P21/06;C12P7/00;C12P11/00;C07K1/13 |
主分类号 |
A61K31/20 |
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