RADICICOL DERIVATIVES

摘要

Radicicol derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, wherein R<1> and R<2> may be the same or different and each represents hydrogen, alkanoyl, alkenoyl or tert-butyldimethylsilyl; and (1) when X represents halogeno, then Y represents oxygen or R<4>-O-N (R<4> being hydrogen or (un)substituted lower alkyl) and R<3> represents hydrogen, alkanoyl, alkenoyl, etc.; while (2) when X is combined with R<3> to represent a single bond, Y represents R<4B>-O-N (R<4B> being the same as R<4>). The derivatives have a tyrosine kinase inhibitory activity and thus have various pharmacological activities such as antitumor, antibacterial and immunosuppressive effects.