NOVEL N-SULFOXY ANHYDRIDES, PROCESS FOR THE PREPARATION THEREOF AND ITS USE FOR THE PREPARATION OF BIOACTIVE SUBSTANCES HAVING ACE INHIBITORY ACTION

摘要

Novel N-sulfoxy anhydrides, a process for the preparation thereof and its use for the preparation of bioactive substances having ACE inhibitory action. Novel compounds of formula (III), wherein R1 represents PhCH2-CH2- or CH3CH2-CH2- and R2 represents methyl or R3-NH-(CH2)3-CH2-, wherein R3 has the meaning of amino protective group, are disclosed. They are used as intermediates in the synthesis of ACE inhibitors, especially of enalapril and trandolapril.