发明名称 |
Transgenic mouse for the neuronal expression of HIV gp160 |
摘要 |
The present invention relates to a transgenic non-human mammal, whose germ cells and somatic cells contain a recombinant env gene sequence which is operably linked to a promoter effective for the expression of the gene in the neuronal tissues of the mammal and effective for the simulation of neurological syndromes associated with HIV-1, the gene being introduced into the mammal, or an ancestor of the mammal, at an embryonic stage. The transgenic non-human mammal is such that transcription of the env gene may be under the control of a promoter sequence, such as a neuron specific promoter of human neurofilament light gene (NFL). The promoter can be synthetic or inducible. The transgenic non-human mammal can be a rodent, such as a mouse.
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申请公布号 |
US5569827(A) |
申请公布日期 |
1996.10.29 |
申请号 |
US19940254395 |
申请日期 |
1994.06.06 |
申请人 |
UNIVERSITE DE MONTREAL |
发明人 |
KESSOUS-ELBAZ, ALL+E,ACU E+EE GRIA;MICHAUD, JEAN;BERRADA, FOUAD |
分类号 |
A01K67/027;C07K14/16;C12N15/85;(IPC1-7):C12N15/00;C07H21/02 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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