Polylactic acid-based implant susceptible of bioresorption containing and antibiotic

摘要

PCT No. PCT/FR92/00231 Sec. 371 Date Dec. 8, 1993 Sec. 102(e) Date Dec. 8, 1993 PCT Filed Mar. 13, 1992 PCT Pub. No. WO92/16193 PCT Pub. Date Oct. 1, 1992Implantable poly(lactic acid)-based pharmaceutical composition which comprises at least one water soluble antibiotic in particle form with controlled dimensions, less than 100 mu m uniformly dispersed in an amorphous poly(lactic acid) matrix, said composition being in ground powder or thin film form. Application especially in initiating local internal antibiotic therapy by the gradual release of the antibiotic substance.