| 摘要 |
The invention concernes borneol esters of general formula (I), in which R1 means T-C(O)-CH(OR6)-CH(NR7aR7b)-R8, C(O)-CH(OR6a)-CH¢NR7(C(O)-CH(OR6b)-CH(NR7aR7b)-R8a)!-R8b; R7a R7b are identical or different and means R7; R7 means hydrogen, A, -C(O)R12, -C(O)OR12, -C(O)SR12, -C(O)NHR9d, -C(O)NR9dR9e, SO2R12, C1-C10 alkyl; R8a, R8b are identical or different and mean R8; R8 means (i), heteroaryl substituted by X3, C7-C16 aralkyl, alkyl; A is B-¢O- (CH2)t-C(O)!0 or 1-, farnesyl-P(O)(OR9d)-O-(CH2)t-C(O)-; B means protein kinase-inhibitors or farnesyl protein transferase-inhibitors such as for example farnesyl (ii); and T is a bond, Zi or a group (iii). The borneol esters can influence tubulin polymerisation and tubulin depolymerisation.
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