| 摘要 |
<p>A skin patch is disclosed for usage in the delivery of a contactant to human skin for the purpose of treating medical conditions responsive to contact immunotherapy. The skin patch specifically induces a cell-mediated contact dermatitis in the treatment of skin disorders. Its anticipated use pertains to treatment of human papilloma virus infections, or warts. In a first embodiment, a pressure activated single chambered skin patch is topically applied and used for controlled release of contactant to human skin from within an enclosing shroud (10). In a second embodiment, a pressure activated two chambered skin patch having a solvent containment chamber (27) and a contactant containment chamber (28) is topically applied and used for controlled release of a contactant to human skin. Alternatively, a single chambered skin patch including a shroud (10) and gel matrix (35) is topically applied and hydrated by the contacted skin for release of contactant. In addition, a flared shroud region (40) can be provided between the containment portion of the shroud and a surrounding adhesive flange to enlarge the area treated upon release of the contactant. The contactants include dinitrochlorobenzene, diphenylcyclopropenone, squaric acid dibutyl ester, and their derivatives.</p> |
