发明名称 4-aryl-3-(heteroarylureido)-1,2-dihydro-2-oxo-quinoline derivatives as antihypercholesterolemic and antiatherosclerotic agents
摘要 PCT No. PCT/US92/10886 Sec. 371 Date Oct. 18, 1994 Sec. 102(e) Date Oct. 18, 1994 PCT Filed Dec. 21, 1992Compounds of the formula <IMAGE> (I) the pharmaceutically acceptable salts thereof wherein R2, R3, R4, m, X and Q are as defined below, and novel intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
申请公布号 US5565472(A) 申请公布日期 1996.10.15
申请号 US19940256303D 申请日期 1994.10.18
申请人 PFIZER INC. 发明人 HAMANAKA, ERNEST S.
分类号 C07D215/38;C07D401/12;(IPC1-7):A61K31/47;C07D215/22 主分类号 C07D215/38
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