| 摘要 |
A device and method for performing particle separation. Separation and purification of biological macromolecules are important steps in basic molecular biology research and biotechnology product development. Throughout the years researchers have worked on developing different and better techniques. The present invention is directed to a new technique for separation of charged particles by applying a magnetic field parallel to the axis of rotation during centrifugation. Magnetocentrifugation performed according to the present invention thus enhances the separation of charged particles under centrifugation by adding a magnetically induced force, namely a Lorentz force, in addition to centrifugal, buoyant, and frictional forces. The technique of magnetocentrifugation may be utilized for separating particles with similar densities but different charges, and may be used for free as well as immobilized charged macromolecules such as proteins and DNA.
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