CATECHOLAMINE SUBSTITUTES SUITABLE AS β-AGONISTS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, PROCESS FOR TREATING DISEASES

摘要

FIELD: medicine. SUBSTANCE: claimed invention describes compounds of formula:or pharmaceutically acceptable salts thereof, wherein A represents bond, -(CH)- or -CH(B)- in which n is integer of 1 to 3 and B represents CN, -CN,-CON(R)Ror -COR; Ris lower alkyl, aryl or aryl alkyl; Ris hydrogen, hydroxy group, alkoxy group, CHOH, cyano group, -C(O)OR, -COH, -CONH, tetrazol, -CHNHor halogen; Ris hydrogen, alkyl, heterocycle or a radical of formula:, Ris hydrogen, alkyl or B; R, R, R, Rand Rare hydrogen, alkoxy group lower alkyl, halogen, OH, CN, -(CH), RCOR, CON(R)R, CON(R)OR, COR, SR, SOR, SOR, N(R)SOR, -N(R)R, -NPCOR, OCHCON(R)R, -OCHCORor aryl or Rand Ror Rand Rtogether with carbon atoms to which they are attached form aryl or heterocycle; Rand Rare hydrogen or lower alkyl; Ris lower alkyl; Ris hydrogen, lower alkyl, alkyl, cycloalkyl, arylalkyl, aryl or heterocycle or Rand Rmay together with carbon atom to which they are attached form heterocycle, and if A represents bond or (CH)and Ris hydrogen or unsubstituted alkyl, then Ris B or substituted alkyl. There compounds are β-adrenergic receptor agonists and are useful for treating diabetes, obesity and gastroenteric diseases. EFFECT: improved properties of the pharmaceutical compositions.