AROMATIC HYDROXYETHERS

摘要

This invention is directed to physiologically active compounds of formula (I), wherein R<1> is optionally substituted alkyl, R<2> is optionally substituted aryl or heteroaryl, A is cycloalkyloxy, cycloalkylalkoxy or alkoxy carrying one or more hydroxy moieties, the cycloalkyl moieties optionally further substituted by one or more methylene or lower alkyl groups, Q<1>, Q<2> and Q<3> each represents CH or CX or nitrogen, Z<1> is oxygen or sulphur, Z<2> is an NH or methylene and X is halogen and N-oxides thereof, and their esters, and prodrugs, pharmaceutically acceptable salts, and solvates (e.g. hydrates), thereof. Such compounds inhibit the production or physiological effects of TNF and inhibit cyclic AMP phosphodiesterase. The invention is also directed to pharmaceutical compositions containing compounds of formula (I), their pharmaceutical use and methods for their preparation.