发明名称 |
MONOMERIC INSULIN ANALOG FORMULATIONS |
摘要 |
The present invention discloses various parenteral pharmaceutical formulations having a protracted effect, which comprise: a sterile aqueous suspension of about 20 U/mL to about 500 U/mL insulin analog, about 5 mg/mL to about 10 mg/mL sodium chloride, about 0.2 to about 2.0 mg/mL physiologically acceptable buffer, a zinc ion content of about 0.07 mg/mL to about 0.1 mg/mL, and a physiologically acceptable preservative at a pH of about 6.5 to about 7.8; such that less than 5 % of the analog present in the suspension is in the dissolved state.
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申请公布号 |
WO9630040(A1) |
申请公布日期 |
1996.10.03 |
申请号 |
WO1996US04424 |
申请日期 |
1996.03.28 |
申请人 |
ELI LILLY AND COMPANY;DE FELIPPIS, MICHAEL, R.;FRANK, BRUCE, H. |
发明人 |
DE FELIPPIS, MICHAEL, R.;FRANK, BRUCE, H. |
分类号 |
A61K38/28;A61K38/00;C07K14/62;(IPC1-7):A61K38/28 |
主分类号 |
A61K38/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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