发明名称 |
DILTIAZEM CONTROLLED RELEASE FORMULATION |
摘要 |
A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50 % by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) from 50 % to 80 % by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and (c) a unit dose containment system.
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申请公布号 |
CA2215378(A1) |
申请公布日期 |
1996.10.03 |
申请号 |
CA19962215378 |
申请日期 |
1996.03.13 |
申请人 |
ANDRX PHARMACEUTICALS, INC. |
发明人 |
CHEN, CHIH-MING |
分类号 |
A61K9/52;A61K9/50;A61K9/58;A61K31/55;A61K31/554;A61K47/30;(IPC1-7):A61K31/55;A61K9/22;A61K9/30 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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