Piperidinyl-2-alkyl subst. linear polyamines for the reduction of intracellular, endogenic polyamine levels such as putrescine, spermidine and spermine, and their impact on cell proliferation

摘要

PCT No. PCT/EP96/00898 Sec. 371 Date Sep. 15, 1997 Sec. 102(e) Date Sep. 15, 1997 PCT Filed Mar. 4, 1996 PCT Pub. No. WO96/28425 PCT Pub. Date Sep. 19, 1996The invention relates to compounds of formula (I) (I) wherein either R1 is hydrogen and R2 is lower alkyl lower alkenyl or lower alkynyl, m is 3 or 4 and n is 2 or 3; or R1 and R2 together are tetrainethylene, m is 3 or 4 and n is 2; or salts thereof. The compounds of formula (I) influence polyamine biosynthesis and have antiproliferative activity as well as an action against protozoans.