| 摘要 |
PURPOSE: To obtain a pharmaceutical preparation which comprises a water-insoluble macromolecular membrane containing a water-soluble medicine and a gel-forming material and can control its sustained release of the medicine by controlling the number and size of the fine pores in the membrane and the kind and amount of the gelforming material. CONSTITUTION: In this sustained release preparation, the water-soluble and low- molecular-weight medicine and the gel-forming material are contained in the spaces surrounded by a water-insoluble macromolecular membrane having fine pores and the sustained release of the medicine is controlled by specifying the number and size of the fine pores in the water-insoluble membrane and selecting the kind and amount of the gel-forming material. The gel-forming material is suitably a polyacrylic acid polymer, particularly a carboxy-vinyl polymer. This preparation is particularly produced by allowing a matrix comprising a water-insoluble macromolecular material such as ethyl cellulose and a water-insoluble low-molecular-weight material such as stearic acid to include an ionic and chelate low-molecular-weight medicine and can release the medicinal ingredient substantially in the zero-order reaction, whiel the initial burst is being suppressed. The content of the medicine is 0.1-50% in this preparation.
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