| 摘要 |
FIELD: biochemistry, peptide chemistry. SUBSTANCE: protease inhibitor of Kunitz type, in part, inhibitor of tissue factor metabolism has the followingaminoacidsequence:X-Asp-Phe-Cys-Phe-Leu--Glu-Glu-Asp--X-Gly-X-Cys-X, X, X, X, X, X-Tyr-Phe-Tyr-Asn-Asn-Glu-Thr- -Lys-Gln-Thr-Lys-Gln-Cys-Glu-Arg-Phe-X-Tyr-Gly-Gly-Cys-X, X, X- -Met-Asn-Phe-X-Thr-Leu-Glu-Gly-Cys-Lys-Asn-Ile-Cys-X-Asp- -X(sequence ID N 1) where Xis H or 1-5 natural amino acid residues for exception Cys; every of X-Xmeans independently natural amino acid residue, and Xmeans OH or 1-5 natural amino acid residues for exception Cys; at condition that at least one of amino acid residues X-Xdistincts of the corresponding amino acid residue of native sequence. EFFECT: enhanced effectiveness of inhibitor. |
