| 摘要 |
New dehydrooligopepetides which bear, as one terminal substituent, an optionally substituted alkyl or alkenyl, optionally substituted aryl, optionally substituted heterocyclic radical, optionally substituted aralkyl or aralkenyl or a carbamoyl group and as the other terminal substituent a hydroxyl or amino, an optionally substituted alkylamino, optionally substituted arylamino, optionally substituted aralkylamino, an optionally substituted nitrogen-containing heterocyclic radical with five or six ring members optionally containing a further heteroatom, optionally substituted aralkoxy, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkylthio group or optionally substituted hydrazine demonstrate histolytic and tumor-resolving activity. The compounds are prepared by either hydrolyzing or aminolyzing the corresponding 2,4-disubstituted 5(4H)-oxazolones. |
