| 摘要 |
<p>PURPOSE: To obtain the subject new compound useful as an medicinal intermediate, or as a raw material for agrochemicals and organic chemical, products. CONSTITUTION: This new compound, a 3-aminopyrrolidine derivative, is expressed by the formula (R is an alkyl), e.g. 1-formyl-3-t-butoxycarbonyl aminopyrrolidine. The compound of formula I is obtained by reaction between 3-amino-1-formylpyrrolidine and a dialkyl dicarbonate in a solvent (e.g. methanol) at-30 to 100 deg.C for 0.1-60h. The amount of the dialkyl dicarbonate to be used is 1.0-1.5 equivalent times the 3-amino-1-formylpyrrolidine. The compound of the formula, because formyl group lies introduced as the protecting group for the amino group on its 1-site, enables the protecting group to be easily eliminated under basic conditions; therefore a sequence of reactions, i.e., elimination of the protecting group followed by reaction of the amino group on the 1-site with another electrophilic agent, can be conducted without the need of using any special reaction unit.</p> |
