摘要 |
Compounds of the formula: <IMAGE> (1) or the amides, esters or salts thereof, wherein: L is an electron withdrawing leaving group; Sx is S=O, O=S=O, S=NH, HN=S=O, Se=O, O=Se=O, Se=NH, HN=Se=O, S+R4 wherein R4 is alkyl (1-6C), or O-C=O or HN-C=O; each R of R1, R2 and R3 is independently H or a noninterfering substituent; n is 0, 1 or 2; Y is selected from the group consisting of <IMAGE> <IMAGE> <IMAGE> and <IMAGE> wherein m is 1 or 2; and AAC is an amino acid linked through a peptide bond to the remainder of said compound of formula 1, are disclosed. These compounds are useful prodrugs for selective treatment of target tissues which contain compatible glutathione S-transferase (GST) isoenzymes, and simultaneously elevate the levels of GM progenitor cells in bone marrow.
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