| 摘要 |
PROBLEM TO BE SOLVED: To optimize materials such as antibodies or antigens, etc., to be used in immunoassay, by performing an immune sensitization with a specific peptide or peptide derivative. SOLUTION: This provides an antigen and an antibody to a substance decomposed and produced from a type I collagen in humor, which specifically recognize the type I collagen or an amino acid sequence of Va-Gly-Leu-Gly in frequents of the type I collagen. The amino acid sequence is recognized in the collagen decomposed substance included in humor. In order to produce the antibody, animals are sensitized with a synthetic peptide or peptide derivative including an amino acid sequence corresponding to a sequence number 1 or a partial sequence including at least an amino acid sequence Val-Gly-Leu- Gly. The synthetic peptide preferably includes 6 or more amino acids. An amino acid bonded to the sequence Val-Gly-Leu-Gly is preferably bonded to an N terminal or C terminal of the sequence.
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