| 摘要 |
<p>Novel amino acid derivatives having an N,N-dialkylaminophenyl group represented by general formula (I), wherein R1 represents hydrogen, lower alkyl, phenyl lower alkyl, lower alkanoyl or benzoyl, provided that the phenyl ring in the phenyl lower alkyl or benzoyl may be substituted by halogeno, lower alkyl or lower alkoxy; R2 represents carboxyl optionally converted into ester, amide or hydroxamic acid; R3 represents lower alkyl; R4 represents lower alkyl; A1 represents lower alkylene optionally substituted by phenyl, provided that the phenyl group may be substituted by halogeno, lower alkyl or lower alkoxy; A2 represents lower alkylene; A3 represents lower alkylene; and Z represents S or O. The compounds have inhibitory effects on LTA and hydrolase and are useful as a drug, in particular, a remedy for diseases in which LTB¿4? participates such as rheumatism, psoriasis, inflammatory intestinal diseases, gout, cystic fibrosis, etc.</p> |
