Production of recombinant human interferon beta2B

摘要

Human interferon-beta2A and interferon-beta2B are produced in purified form by recombinant DNA techniques. Two separate human genes have been identified which code for the production of IFN- beta 2A and IFN- beta 2B, respectively. The sequence of IFN- beta 2A cDNA is established. These genes and cDNA have been cloned into mammalian cells with an SV40 early promoter sequence and such genomic clones are capable of producing IFN- beta 2A and IFN- beta 2B. The antiviral activity of such recombinant IFN- beta 2A and IFN- beta 2B is demonstrated as well as other biological activity identifying them as human interferons.