PROCESS FOR THE PREPARATION OF A SOLID PHARMACEUTICAL DOSAGE FORM

摘要

The invention relates to a process for the preparation of a solid pharmaceutical dosage form comprising a carrier and, as active ingredient, a compound which is susceptible to sublimation during the preparation process, which process includes the steps of solidifying a mixture of the compound and carrier in a solvent and subsequently removing the solvent from the solidified mixture, characterised in that a pH modifier is added to the mixture prior to solidification. In an alternative or further step, the solidified mixture is maintained within a specific temperature range for a specified period of time prior to removal of the solvent.