Use of vinpocetine derivatives for inhibiting production or secretion of amyloid beta protein

摘要

PCT No. PCT/JP96/00265 Sec. 371 Date May 10, 1996 Sec. 102(e) Date May 10, 1996 PCT Filed Feb. 8, 1996 PCT Pub. No. WO96/25161 PCT Pub. Date Aug. 22, 1996A pharmaceutical composition for inhibiting production or secretion of amyloid beta protein, which comprises a compound of the formula (I): wherein ring A is an optionally substituted benzene ring, R represents OR1, or SR1, wherein R1, R2 and R3 are the same or different and each is selected from a hydrogen atom, an optionally substituted hydrocarbon group or R2 and R3, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen-containing heterocyclic group, and Y is an optionally substituted alkyl group, or a pharmaceutically acceptable salt thereof, if necessary, with a pharmaceutically acceptable excipient, carrier or diluent.