发明名称 Bridged-diazabicycloalkyl quinolone carboxylic acids and esters.
摘要 <p>Compounds of the formula &lt;CHEM&gt; and pharmaceutically acceptable acid addition salts thereof, wherein R&lt;1&gt; is hydrogen, (C1-C6)alkyl, or a pharmaceutically acceptable cation; R&lt;2&gt; is ethyl, fluoroethyl, p-fluorophenyl, p-hydroxyphenyl or cyclopropyl; R&lt;3&gt; is fluorine or hydrogen; and R&lt;4&gt; is &lt;CHEM&gt; wherein n is 1 or 2 and R&lt;5&gt; is hydrogen or (C1-C3)alkyl are disclosed. Also disclosed are antibacterial pharmaceutical compositions comprising the foregoing compounds, methods of using the compounds in treating bacterial infections, and intermediates for the preparation of the compounds.</p>
申请公布号 EP0297858(A2) 申请公布日期 1989.01.04
申请号 EP19880305925 申请日期 1988.06.28
申请人 PFIZER INC. 发明人 FOX, EDWARD KLEINMAN
分类号 A61K31/435;A61K31/55;A61P31/04;C07D471/08 主分类号 A61K31/435
代理机构 代理人
主权项
地址