发明名称 |
Fremgangsmåte for fremstilling av preparat ved vedvarende frigjöring |
摘要 |
A method of production of sustained-release microcapsules that comprises obtaining microcapsules comprising a bioactive substance that are encapsulated with a biodegradable polymer, and thermally drying the obtained microcapsules at a temperature not lower than the glass transition temperature of the biodegradable polymer for about 24 to about 120 hours to produce the sustained-release microcapsules comprising, relative to the weight of the sustaind-release microcapsule, not less than 60% (w/w) of the biodegradable polymer, possessing pharmaceutical characteristics clinically excellent in that a bioactive substance is released at constant rate over a very long period of time from just after administration with dramatically suppressed initial release of the bioactive substance in excess just after administration and with minimum remaining organic solvent. |
申请公布号 |
NO963678(D0) |
申请公布日期 |
1996.09.03 |
申请号 |
NO19960003678 |
申请日期 |
1996.09.03 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES LTD |
发明人 |
IGARI, YASUTAKA;TAKADA, SHIGEYUKI;KOSAKAI, HIROSHI |
分类号 |
A61K9/16;A61K9/50;A61K9/52;(IPC1-7):A61K |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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