PROCEDURES FOR OBTAINING RIBO-C-NUCLEOSIDES

摘要

Novel procedures for obtaining ribo-C-nucleosides, including especially 2- beta -D-ribofuranosylthiazole-4-carboxylamide (tiazofurin) and 2- beta -D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures involve introducing a cyano group at the (1') position of a ribose, directly or indirectly converting the cyano group to HN=C-OR1 or thicarboxylamide wherein R1 is a lower alkyl, forming the group which substituted for the cyano group into a heterocyclic ring containing an ester, and converting the ester into an amide.