| 摘要 |
PURPOSE: To obtain the subject new derivative which is a specific 1,3-oxathiolane derivative, capable of manifesting excellent effects on clinically important aspergillosis or candidasis, having high safety and useful as an orally or an intravenously administrable antifungal agent, etc. CONSTITUTION: This (R)-(+)-5-(2,4-difluorophenyl)-4,4-dimethyl-5-(1H-1,2,4-triazol-1- ylmethyl)-1,3-oxathiolane (salt) which is a new compound represented by formula I. The compound is capable of manifesting excellent effects on aspergillosis or candidasis which is clinically especially important and useful as an orally or an intravenously administrable antifungal agent, etc. The compound is obtained by reacting (R)-(-)-2-(2,4-difluorophenyl)-3-mercapto-3-methyl-1-(1H-1,2,4- triazol-1-yl)butan-2-ol represented by formula II with bromochloromethane in tetrahydrofuran. |
