发明名称 |
TCF mutant |
摘要 |
The present invention relates to TCF mutant having a novel amino acid sequence which is obtained by mutagenesis of one or more amino acid between N-terminus and the first kringle of the amino acid sequence of native TCF and has lowered affinity to heparin and/or elevated biological activity. The present TCF mutant is prepared by gene manipulation of TCF. The TCF mutants of the present invention have proliferative activity and/or growth stimulative activity in hepatocyte and beneficial as a therapeutic agent for various hepatic diseases and an antitumor agent. |
申请公布号 |
ZA9510982(B) |
申请公布日期 |
1996.08.22 |
申请号 |
ZA19950010982 |
申请日期 |
1995.12.27 |
申请人 |
SNOW BRAND MILD PRODUCTS CO., LTD. |
发明人 |
MASAHIKO KINOSAKI;KYOJI YAMAGUCHI;FUMIE KOBAYASHI;MASAAKI GOTO;AKIHIKO MURAKAMI;MASATSUGU UEDA;KANJI HIGASHIO;YASUSHI YAMASHITA |
分类号 |
A61K38/00;C07K14/475;C12N15/19 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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