发明名称 |
PEPTIDES AND PEPTIDOMIMETICS WITH STRUCTURAL SIMILARITY TO HUMAN p53 THAT ACTIVATE p53 FUNCTION |
摘要 |
The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
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申请公布号 |
WO9625434(A1) |
申请公布日期 |
1996.08.22 |
申请号 |
WO1996US01535 |
申请日期 |
1996.02.16 |
申请人 |
THE WISTAR INSTITUTE;BAYER CORPORATION;HALAZONETIS, THANOS;HARTWIG, WOLFGANG |
发明人 |
HALAZONETIS, THANOS;HARTWIG, WOLFGANG |
分类号 |
G01N33/15;A61K38/00;A61K38/17;A61P9/00;A61P9/10;A61P35/00;A61P37/00;A61P43/00;C07K14/47;C07K14/82;C12N15/00;C12N15/09;C12R1/91;(IPC1-7):C07K14/82;G01N33/574;G01N33/68;A61K38/04 |
主分类号 |
G01N33/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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