| 摘要 |
PCT No. PCT/US93/02311 Sec. 371 Date Oct. 6, 1994 Sec. 102(e) Date Oct. 6, 1994 PCT Filed Mar. 12, 1993 PCT Pub. No. WO93/20059 PCT Pub. Date Oct. 14, 1993This invention relates to novel hydrazide acyl hydrazinium derivatives of certain 3,4-dihydro-2H-1-benzopyrans of the formula <IMAGE> (1) the stereoisomers and mixtures thereof, their inner salts, and the pharmaceutically acceptable salts thereof wherein R is H or C1-6 alkyl, R1 is C1-6 alkyl, R2 is H or -C(O)R,R3 and R4 are independently C1-6 alkyl; R5 is C1-6 alkyl, or <IMAGE> with R8 being H or halogeno, n is zero, 1, 2, or 3 and is a halide, -S(O)3R6, or nothing when the inner salt is formed R6 is H, C1-6 alkyl, phenyl or 4-methylphenyl, to the intermediates, processes and techniques for their preparation, to their ability to manifest the property of being free radical scavengers, and to their end-use application in the treatment of disease conditions capable of being ameliorated by free radical scavengers.
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