| 摘要 |
A process for enhancing the security of implantable surgical devices secured to bone tissue comprising implanting in bone tissue a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: (a) a material made from monomers of the formula: CHR1=CX1Y1 wherein X1 and Y1 are each strong electron withdrawing groups, and R1 is hydrogen or, provided that X1 and Y1 are both cyano groups, a C1-C4 alkyl group; (b) a semi-crystalline aliphatic poly(ester) of the formula: ¢-O-R11-C(O)-!y, wherein R11 is selected from the group consisting of -CR12H-, -(CH2)3-O-, -CH2-CH2-O-CH2-, CR12H-CH2, -(CH2)4-, -(CH2)z-O-C(O)- and -(CH2)z-C(O)-CH2-; R12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and (c) a slurry of water and a calcium containing compounds with the general formula: M2+10-nN1+2n(WO43-)6mU2-where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO4 is an acid radical and W is phosphorus, vanadium, sulfur, siliccn, or is substituted in whole or part with carbonate (CO32-); and U is a halide, hydroxide, or carbonate; pro in an amount effective to increase the amoun force necessary to remove the implanted surgical device. Additionally provided is a surgical device that is at least partially coated with at least one biocompatible adhesive and/or sealant.
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