| 摘要 |
A method is provided for the synthesis of an alpha -methyl- beta -acylthiopropionate of formula I: selected from C1-C6 alkyl, phenyl or substituted phenyl of the formula C6H2R3R4R5 wherein R3, R4 and R5 are independently selected from hydrogen, lower alkyl, F, Cl, Br, NO2, CN or R6O wherein R6 is lower alkyl. The method comprises reacting methyl methacrylate with a thiocarboxylic acid at a mole ratio ranging between about 1:1 and about 2:1 and at a temperature ranging between 40 DEG C. and about 150 DEG C. The reaction is conducted either in the presence of an organic solvent or in the presence of polymerization inhibitors for approximately 3 to 6 hours. alpha -Methyl- beta -acyl-thiopropionates are obtained economically by the disclosed method in high purity and yields and in shorter reaction times relative to conventional processes.
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