Therapeutic polyamines

摘要

Therapeutic polyamines useful as a cancer chemotherapeutic agents, including molecules having a formula R1-NH-(CH2)x-NH -(CH2)x-NH-(CH2)y-NH-(CH2)z-NH-R, wherein R1 and R2 are hydrocarbon chains having 1 to 5 carbons and w, x, y and z are integers of 1 to 10, are disclosed. One such molecule is N1, N19-bis(ethylamino)-5,10,15-triazanonadecane, which is longer than spermine. This preferred compound may be used alone or in combination with other therapeutic agents, such as 1,3-bis(2-chloroethyl)-1-nitrosourea or cis-Pt.