| 摘要 |
Methods to treat the defects in skeletal tissues characterized by protecting the marrow cells adjacent to the defects from apoptotic and/or necrotic cell death are disclosed. The methods provide additional benefits which are to reduce inflammation and irritation in the marrow tissues and assist promoting new skeletal tissue formation to an application of a simple skeletal formation or regeneration activity such as a bone growth factor. The methods may involve application of pharmacologically active peptidic compounds comprising about 15 to about 28 amino acids in their sequences characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan attachment motif, and/or a calcium binding motif. The sequence may be a 23 amino acid sequence formulated for injection, topical application, or dispersed in a matrix such as collagen or a tooth filling composition or gum patch and administered to enhance bone/tooth growth or prevent loss.
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