Pharmaceutical granulated composition and method for preparing same

摘要

PCT No. PCT/RU92/00004 Sec. 371 Date Sep. 10, 1993 Sec. 102(e) Date Sep. 10, 1993 PCT Filed Jan. 10, 1992 PCT Pub. No. WO93/13756 PCT Pub. Date Jul. 22, 1993.A granulated composition for direct tableting, comprising non-pressed or difficulty pressed, water-soluble, crystalline pharmaceutical substances, binder, lubricant and water, contains at least 98 wt. % of a pharmaceutically active component. The tablets manufactured from said composition have high hardness and the controllable time of dissolution. A method for preparing said composition consists in that the powder of a pharmaceutical substance is pre-granulated with water or its aqueous solution, the resultant granulate is then subjected to subsequent granulation with a binder solution, dried and powdered with lubricant.