发明名称 |
Parenteral amino acid formulations for the inhibition of systemic hypotension associated with nitric oxide production |
摘要 |
An anti-hypotensive formulation comprising an essentially arginine-free or low arginine (less than about 0.1%, most preferably, about 0.01%) containing mixture of amino acids is provided. The invention in particular embodiments of the anti-hypotensive formulation includes ornithine, citrulline or both. A method for prophylaxis and treatment of systemic hypotension in an animal is provided. Most particularly, a method for treating hypotension caused by nitric oxide synthesis through administering a low or essentially arginine-free parenteral formulation to an animal, so as to reduce or eliminate nitric oxide synthesis is described. A method for treating an animal in septic shock is also disclosed, comprising administering to the animal an anti-hypotensive formulation comprising a mixture of amino acids, which is essentially arginine free.
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申请公布号 |
US5534545(A) |
申请公布日期 |
1996.07.09 |
申请号 |
US19930152050 |
申请日期 |
1993.11.12 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
KILBOURN, ROBERT G.;GRIFFITH, OWEN W.;GROSS, STEVEN S. |
分类号 |
A61K31/415;A61K31/715;A61K38/04;A61K38/19;(IPC1-7):A61K31/195;A61K31/385;A61K31/40 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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