1,4-DIHYDRODIOXINS AND RELATED COMPOUNDS AS DNA CLEAVING REAGENTS
摘要
The present invention relates to a class of 1,4-dihydrodioxin masked quinone compounds which are useful as DNA or RNA cleaving reagents. These compounds may additionally include moieties which target the compounds to specific base sequences on the DNA or RNA molecule to permit site-specific cleavage. The process for using these compounds in a UV or short wavelength visible light-activated reaction for cleaving DNA, as well as pharmaceutical compositions containing these compounds, are also disclosed.
申请公布号
WO9620205(A1)
申请公布日期
1996.07.04
申请号
WO1995US16434
申请日期
1995.12.21
申请人
UNIVERSITY OF CINCINNATI;WILSON, ROBERT, MARSHALL;SCHNAPP, KARLYN, A.;HARSCH, ANDREAS;KELLER, STEPHEN, J.;SCHLEMM, DONNA, J.
发明人
WILSON, ROBERT, MARSHALL;SCHNAPP, KARLYN, A.;HARSCH, ANDREAS;KELLER, STEPHEN, J.;SCHLEMM, DONNA, J.