发明名称 |
RECOMBINANT POXVIRUS INTERNAL CORES |
摘要 |
<p>What is described is a modified recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, having an internal core containing DNA from a non-pox source in a nonessential region of the poxvirus genome. The recombinant poxvirus is modified by disassociating the internal core from outer membranes of the poxvirus. The DNA codes for and expresses a gene product in a cell cultured in vitro and in a host in vivo without productive replication of the virus in the cell or in the host. What is also described is a vaccine containing the modified recombinant poxvirus for inducing an immunological response in a host inoculated with the vaccine.</p> |
申请公布号 |
EP0515433(B1) |
申请公布日期 |
1996.07.03 |
申请号 |
EP19910903450 |
申请日期 |
1991.01.07 |
申请人 |
HEALTH RESEARCH, INCORPORATED |
发明人 |
PAOLETTI, ENZO |
分类号 |
A61K39/275;A61K39/295;C12N5/10;C12N7/00;C12N7/01;C12N15/09;C12N15/863;C12P21/00;C12R1/91;C12R1/92;(IPC1-7):C12N15/86;A61K39/285;C12N7/06 |
主分类号 |
A61K39/275 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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